Eastern Panama Vacations from $685

Book a Hotel + Flight or Car together to unlock savings

Photo by Nico Barner
  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

    Rest easy

    Plan, book, and manage your trip all in one place

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Panamonte
Central Hotel Bocas del Toro
Central Hotel Panama Casco Viejo
Isla Palenque Member of the Cayuga Collection
Villa Marina Lodge & Condos
Don't see what you're looking for?
See all available trips from Columbus to Eastern Panama
View all trips

Discover the most popular places to visit in Eastern Panama

Eastern Panama Hotel Deals

Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
$117 nightly
The price is $129 total per night from Oct 23 to Oct 24
$129 total
Oct 23 - Oct 24
Total with taxes and fees
9.6/10 Exceptional! (5 reviews)
Perfect location

Reviewed on Aug 10, 2025

Ranchos de Chalia
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
10/10 Exceptional! (3 reviews)
Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special.

Reviewed on Sep 5, 2025

Ordovician Beach Resort
 San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island, Narganá, Guna Yala
$169 nightly
The price is $186 total per night from Oct 30 to Oct 31
$186 total
Oct 30 - Oct 31
Total with taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.