Name: San Blas Paradise Private Cabins on Shipwreck Island - meals included
Price range: $186 total

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Panamonte

Save 100% on your flight

$685

per person

Nov 28 - Dec 3

found 17 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.4/10 Exceptional! (121 reviews)

This is a classic, elegant property that lives up to its reputation. Quality in every regard. On par with some of the finest historic hotels in the country (and I’ve stayed at a few).

Reviewed on Sep 4, 2025

Central Hotel Bocas del Toro

Save 100% on your flight

$950

per person

Jan 3 - Jan 6

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

No reviews

Central Hotel Panama Casco Viejo

Casco Viejo

$834

per person

Dec 4 - Dec 7

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,005 reviews)

perfect location and city. Only comment is the supervisor, a short gentleman, is very aggressive and rude. Shoutout to Barbara, Rene and Jose.

Reviewed on Oct 21, 2025

Isla Palenque Member of the Cayuga Collection

Save 100% on your flight

$2,980

per person

Nov 29 - Dec 3

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

10/10 Exceptional! (6 reviews)

Villa Marina Lodge & Condos

$913

per person

Nov 27 - Dec 2

found 23 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (132 reviews)

Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back

Reviewed on Jul 14, 2025

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Discover the most popular places to visit in Eastern Panama

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

$117 nightly

$129 total

Oct 23 - Oct 24

Total with taxes and fees

9.6/10 Exceptional! (5 reviews)

Perfect location

Reviewed on Aug 10, 2025

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

10/10 Exceptional! (3 reviews)

Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special.

Reviewed on Sep 5, 2025

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San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

$169 nightly

$186 total

Oct 30 - Oct 31

Total with taxes and fees

See all 173 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.