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Eastern Panama Vacations from $819
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The Latest Eastern Panama Vacation Packages
Price found within the past 48 hours. Click for updated prices.
- Decapolis Hotel Panama City
Oct 23 - Oct 29Decapolis Hotel Panama City + Flight
San Francisco6 nights4.0 star property8.6/10 - Excellent (1,711 reviews)Roundtrip • Georgetown (GEO) - Panama City (PTY)GEO - PTY • Nonstop PTY - GEO • Nonstop$1,235$819found 1 day agoper traveler - Central Hotel Panama Casco Viejo
Oct 6 - Oct 11Central Hotel Panama Casco Viejo + Flight
Casco Viejo5 nights4.0 star property9.2/10 - Wonderful (1,013 reviews)"The hotel is as the name indicated, in the center of old town. The location is fantastic. Very convenient. However, as some of the reviews had mentioned, they have live music in the lobby all day until 11pm. I was aware of this and requested that they give us a quiet room. However, we were given a room with windows facing the atrium and were subjected to the music all day. It was not too loud but was quite annoying if you want quietness. Add to this, it was on the 4th floor and next to one..."Reviewed August 6, 2026Roundtrip • New York (EWR) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,938$992found 1 day agoper traveler - Megapolis Hotel Panamá
Oct 6 - Oct 11Megapolis Hotel Panamá + Flight
San Francisco5 nights4.5 star property8.4/10 - Very Good (1,636 reviews)Roundtrip • New York (EWR) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop - Riande Aeropuerto Hotel & Casino
Oct 6 - Oct 11Riande Aeropuerto Hotel & Casino + Flight
Tocumen5 nights4.0 star property8.4/10 - Very Good (1,819 reviews)"there was only one bar and no entertainment at all one restaurant well"Reviewed August 6, 2026Roundtrip • New York (EWR) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,372$913found 1 day agoper traveler - Hotel Riu Plaza Panama
Oct 6 - Oct 11Hotel Riu Plaza Panama + Flight
Bella Vista5 nights5.0 star property9.0/10 - Wonderful (5,779 reviews)Roundtrip • New York (EWR) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,339$951found 1 day agoper traveler
Discover the most popular places to visit in Eastern Panama
Eastern Panama Hotel Deals
9.8 out of 10, Exceptional, (18 reviews)
9.8/10
Exceptional
(18 reviews)
"Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth"
$118 nightly
The price is $131
$131 total
Aug 17 - Aug 18
Total with taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
San Blas Paradise Private Cabins on Shipwreck Island - meals included2.0 star property
15.7 mi from Eastern Panama
$169 nightly
The price is $186
$186 total
Aug 8 - Aug 9
Total with taxes and fees
Cabins on paradise San Blas island
Cabins on paradise San Blas island2.0 star property
58.7 mi from Eastern Panama
$269 nightly
The price is $296
$296 total
Aug 8 - Aug 9
Total with taxes and fees
6.0 out of 10, (1 review)
6.0/10
(1 review)
"Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done."
$122 nightly
The price is $134
$134 total
Aug 7 - Aug 8
Total with taxes and fees
Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Ocean-Front Cabin with private bathroom on San Blas Island2.0 star property
57.5 mi from Eastern Panama
10.0 out of 10, Exceptional, (1 review)
10/10
Exceptional
(1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door. "
$188 nightly
The price is $207
$207 total
Aug 18 - Aug 19
Total with taxes and fees
Cabins in Asserya Island - San Blas paradise - meals included
Cabins in Asserya Island - San Blas paradise - meals included2.0 star property
15.7 mi from Eastern Panama
$132 nightly
The price is $145
$145 total
Aug 7 - Aug 8
Total with taxes and fees
$138 nightly
The price is $152
$152 total
Aug 7 - Aug 8
Total with taxes and fees
Private Bedroom on Paradise San Blas Island
Private Bedroom on Paradise San Blas Island2.5 star property
57.1 mi from Eastern Panama
10.0 out of 10, Exceptional, (1 review)
10/10
Exceptional
(1 review)
"Don’t go expecting a resort and you will thoroughly enjoy yourself. The Guna that run the island are all warm, friendly, helpful. Great snorkelling tours and beautiful clean water. The accommodations are very simple but comfortable. Shared bathroom that was kept very clean. A great place to get away from it all. The ride through the mountain was very potholy and winding so if you get carsick definitely come prepared."
$166 nightly
The price is $183
$183 total
Aug 7 - Aug 8
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.