Name: HOTEL ISLA GRANDE
Rating: 5

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

Bella Vista

$680

per person

Feb 25 - Mar 2

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

9/10 Wonderful! (4,515 reviews)

Every single thing was very nice .

Reviewed on Dec 6, 2025

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,088

per person

Feb 25 - Mar 2

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

Great staff, perfect location, and delicious breakfast.

Reviewed on Dec 4, 2025

Amarla Boutique Hotel Casco Viejo

Casco Viejo

Save 100% on your flight

$1,165

per person

Feb 25 - Mar 2

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

9.6/10 Exceptional! (99 reviews)

Great little hotel in Casco Viejo. Rooms are small, but comfortable. Reception is a bit odd, but service was nice.

Reviewed on Nov 18, 2025

Megapolis Hotel Panamá

San Francisco

$732

per person

Feb 25 - Mar 2

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

8.4/10 Very Good! (1,204 reviews)

Place was great over all

Reviewed on Dec 6, 2025

Dreams Playa Bonita Panama - All Inclusive

Save 100% on your flight

$1,599

per person

Feb 14 - Feb 19

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

7.4/10 Good! (1,002 reviews)

Property was very clean and kept but the little biting flyies were terrible. Get you some off and you will be good

Reviewed on Dec 6, 2025

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Discover the most popular places to visit in Eastern Panama

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ordovician Beach Resort

Isla Grande Isla Grande Colon

10/10 Exceptional! (3 reviews)

Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special.

Reviewed on Sep 5, 2025

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Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón

9.6/10 Exceptional! (10 reviews)

Beautiful tranquility in nature, amazing staff

Reviewed on Nov 23, 2025

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HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province

Fully refundableReserve now, pay when you stay

5/10 (4 reviews)

Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ...

Reviewed on Sep 19, 2025

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See all 170 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.