Eastern Panama Vacation Packages 2026 from $818

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Decapolis Hotel Panama City

San Francisco

$818

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,708 reviews)

El desayuno estaba increíble, el hotel súper limpio, personal atento y perfecta ubicación

Reviewed on Sep 20, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,189

per person

Nov 4 - Nov 11

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (1,012 reviews)

Such a great experience! I’d recommend it to anyone and love to stay again.

Reviewed on Sep 20, 2026

Megapolis Hotel Panamá

San Francisco

$832

per person

Oct 21 - Oct 24

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.4/10 Very Good! (1,693 reviews)

The pool Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly.

Reviewed on Sep 20, 2026

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$844

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Clean room and

Reviewed on Sep 21, 2026

Hotel Riu Plaza Panama

Bella Vista

$889

per person

Nov 4 - Nov 11

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (5,892 reviews)

I spent my honeymoon and was greeted with champagne and an assorted dish of chocolate-covered strawberries and other goodies. The room was very spacious and clean excellent breakfast and the Resturants were convenient with a wide assortments I will definitely stay here again and recommend the Riu. It

Reviewed on Sep 21, 2026

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Stay near popular Eastern Panama attractions

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

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Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

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Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

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Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

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Eastern Panama Hotel Deals

Ordovician Beach Resort

Isla Grande Isla Grande Colon

$416 nightly

$459 total

Oct 1 - Oct 2

Total with taxes and fees

10/10 Exceptional! (14 reviews)

"La comida estaba deliciosa, el staff con excelente atención. La playa privada es un super plus."

Reviewed on Jul 19, 2026

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón

$121 nightly

$134 total

Oct 4 - Oct 5

Total with taxes and fees

9.8/10 Exceptional! (19 reviews)

"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner ..."

Reviewed on Jun 2, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

$188 nightly

$207 total

Sep 22 - Sep 23

Total with taxes and fees

10/10 Exceptional! (1 review)

"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

See all 201 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.