Name: Private Over the Water Cabin on San Blas Island
Rating: 7

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Nomada Republic Hotel El Valle

per person

Oct 21 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

9/10 Wonderful! (34 reviews)

An excellent hotel with great views (on a sunny day). The drive into town is pretty short, so it's a good spot that's both convenient and quiet

Reviewed on Jul 2, 2025

Casa Fofo Family House

Save 100% on your flight

per person

Oct 21 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

No reviews

Central Hotel Bocas del Toro

Save 100% on your flight

per person

Nov 7 - Nov 11

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

No reviews

Villa Botero By Casa Mojito B&B

per person

Oct 21 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Central Hotel Panama Casco Viejo

Casco Viejo

per person

Sep 18 - Sep 22

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (965 reviews)

I like the breakfast style and everything was near by the hotel. I didn’t like the early morning noise. It was just a little bit noisy. Not a big deal.

Reviewed on Aug 14, 2025

Don't see what you're looking for?

See all available trips from Columbus to Eastern Panama

View all trips

Discover the most popular places to visit in Eastern Panama

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

10/10 Exceptional! (2 reviews)

"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the ..."

Reviewed on Jul 25, 2025

Get rates

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

$207 nightly

$228 total

Aug 17 - Aug 18

Total includes taxes and fees

10/10 Exceptional! (9 reviews)

"All was good"

Reviewed on Jul 14, 2025

Private Over the Water Cabin on San Blas Island

9.542876, -78.899058, Narganá, San Blas

7/10 Good! (6 reviews)

"Very nice. And I liked the food"

Reviewed on Aug 14, 2025

Get rates

See all 170 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.