
Eastern Panama Vacations from $730
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Your Eastern Panama Vacation
Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.
The Latest Eastern Panama vacation packages

Mahogany Suites
Reviewed on Mar 11, 2026

Hotel Riu Plaza Panama
Reviewed on Mar 12, 2026

Central Hotel Panama Casco Viejo
Reviewed on Mar 10, 2026

Megapolis Hotel Panamá
Reviewed on Mar 10, 2026

Lesplanade by Wynwood House
Reviewed on Jan 6, 2025
Discover the most popular places to visit in Eastern Panama
Museum of the Kuna Nation
You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.
Porvenir Museum
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
Eastern Panama Hotel Deals

Hotel Cocotal

Ordovician Beach Resort
The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.
Reviewed on Feb 21, 2026

HOTEL ISLA GRANDE
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.
Reviewed on Feb 4, 2026
Find the Best Eastern Panama Vacation Packages
Eastern Panama Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Tocumen Intl. Airport (PTY) |




















